If the GPS (car or hiking) has a usb port, you can load waypoints on from yer compy. Garmin works with hte geocaching.com website very nicely. Others may require a 3rd party program. I use a Garmin Street Pilot c330 in my car to take me to the general location and my handheld Garmin eTrex Legend to get to the cache. For a while, I used the c330 for everything and it worked surprisingly well.